Leiurotoxin-1 Dab7

SK2 channel blocker

Leiuorotoxin-Dab7 (Lei-Dab7) is a mutated version of Leiurotoxin, a peptide identified from the venom of the scorpion Leiurus quinquestriatus hebraeus. The Dab amino acid in position 7 confers to this compound a high selectivity for SK2 channels among other channels. Lei-Dab7 exhibits > 200 fold selectivity for SK2 over SK1, SK3, IK, Kv and Kir channels. The IC50 for SK2 is about 3 nM.

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AA sequence: Ala-Phe-Cys3-Asn-Leu-Arg-Dab-Cys8-Gln-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21-Ile-Gly-Asp-Lys-Cys26-Glu-Cys28-Val-Lys-His-NH2
Disulfide bonds between: Cys3-Cys21, Cys8-Cys 26 and Cys12-Cys28
Length (aa) : 31
Formula:  C141H236N46O39S6
Molecular Weight: 3392.12 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [1061556-49-7] Source: Synthetic
Purity rate: > 95%






Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7

Small-conductance Ca2+-activated potassium type 2 channels regulate the formation of contextual fear memory

Small conductance calcium-activated K+ channels, SkCa, but not voltage-gated K+ (Kv) channels, are implicated in the antinociception induced by CGS21680, a A2A adenosine receptor agonist.