ShK – Stichodactyla toxin

Selective blocker of Kv1.3

ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent potassium channels. It blocks Kv1.3 (KCNA3) potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) respectively with a Kd of 11 pM, 16 pM, 312 pM and 165 pM. Interestingly, it was also demonstrated that ShK potently inhibits the hKv3.2b channel with an IC50 value of approximately 0.6 nM.

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AA sequence: Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OH
Disulfide bonds: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32
Length (aa): 35
Formula: C169H274N54O48S7
Molecular Weight: 4054.85 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 165168-50-3
Source: Synthetic
Purity rate: > 97%

Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model

Modeling the binding of three toxins to the voltage-gated potassium channel (Kv1.3)

Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection

Molecular mechanism of the sea anemone toxin ShK recognizing the Kv1.3 channel explored by docking and molecular dynamic simulations

K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression

Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3.2 channels

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases

Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases

An essential binding surface for ShK toxin interaction with rat brain potassium channels.

Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus