β-Pompilidotoxin

80 240 

β-Pompilidotoxin slows the inactivation of neuronal Navs

β-Pompilidotoxin was isolated from the venoms of two wasps, Anoplius amariensis and Batozonellus maculifrons. This short peptide slows the inactivation of neuronal sodium channels and does not affect cardiac sodium channels.

 

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Description

AA sequence:  Arg-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu-NH2
Length (aa): 13
Formula:   C71H124N22O17
Appearance: White lyophilized solid
Molecular Weight: 1557.91 Da
CAS number: 216064-36-7
Source: Synthetic
Purity rate: > 99%

For research use only

  • OD1: selective Nav1.7 activator
  • Teramoto N., et al. (2012) Resurgent-like currents in mouse vas deferens myocytes are mediated by NaV1.6 voltage-gated sodium channels. Pflugers Arch.
  • Magloire V., et al. (2011) β-pompilidotoxin modulates spontaneous activity and persistent sodium currents in spinal networks. Neuroscience.
  • Yokota H., et al (2001) Modulation of synaptic transmission in hippocampal CA1 neurons by a novel neurotoxin (β-pompilidotoxin) derived from wasp venom. Neuroscience Research
  • Kinoshita E., et al. (2001) Novel Wasp Toxin Discriminates between Neuronal and Cardiac Sodium Channels. Mol. Pharmaco.
  • Konno K., et al. (1998) Isolation and Structure of Pompilidotoxins, Novel Peptide Neurotoxins in Solitary Wasp Venoms. Biochemical and biophysical research communications.

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    β-Pompilidotoxin

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