ω-agatoxin-IVA

Blocker of P/Q-type calcium channel (Cav2.1)

ω-agatoxin-IVA (ω-AGA IVA) is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that ω-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for ω-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the α-1A Ca2+ channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.

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Product code: 11AGA001. Categories: , . Tags: , , .

AA sequence: Lys-Lys-Lys-Cys4-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys12-Lys-Trp-Gly-Gly-Thr-Pro-Cys19-Cys20-Arg-Gly-Arg-Gly-Cys25-Ile-Cys27-Ser-Ile-Met-Gly-Thr-Asn-Cys34-Glu-Cys36-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH
Disulfide bonds: Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34
Length (aa): 48
Formula: C217H360N68O60S10
Molecular Weight: 5202.48 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 145017-83-0
Source: Synthetic
Purity rate: > 97 %

Conotoxin-SO3

Conotoxin-MVIIA

SNX482

Conotoxin-MVIIC

Conotoxin-GVIA

P-type calcium channels blocked by the spider toxin omega-Aga-IVA

Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels

Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta

Molecular pharmacology of high voltage-activated calcium channels

A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels

Modulation of insect Ca(v) channels by peptidic spider toxins

omega-Toxins affect Na+ currents in neurosecretory insect neurons

Ca2+ currents in central insect neurons: electrophysiological and pharmacological properties